The Times Australia
News From Asia

.
The Times Real Estate

.

Gene Solutions Announces Publication of Ground-breaking Study on AI-Driven Tumor-Specific Methylation Atlas

HO CHI MINH, VIETNAM - Media OutReach Newswire - 9 August 2024 - Gene Solutions, a pioneering genetic testing company in South-East Asia, is excited to announce the publication of a new peer-reviewed study that validates the analytical capabilities of its innovative, AI-driven Tumor-Specific Methylation Atlas (TSMA).

The study, published in BMC Journal of Translational Medicine: "Tissue of origin detection (TOO) for cancer tumor using low-depth cfDNA samples through combination of tumor-specific methylation atlas and genome-wide methylation density in graph convolutional neural networks", details the robust analytical validation process which leverages advanced artificial intelligence to deliver precise and reliable tumor origin predictions in multi-cancer early detection.

Gene Solutions Announces Publication of Ground-breaking Study on AI-Driven Tumor-Specific Methylation Atlas

Firstly, the bioinformatics team from Gene Solutions used whole-genome bisulfite sequencing (WGBS) on five types of tumor tissues (breast, colorectal, gastric, liver and lung cancer) and paired white blood cells (WBC) to construct a tumor-specific methylation atlas (TSMA), where 2,945 CpG regions are discovered between tumor types and WBC. The team then implemented a Deep Learning model of Graph Convolutional Neural Network that combines deconvolution scores from the TSMA with other features to achieve an improved tumor of origin prediction accuracy in the validation dataset of 239 low-depth cfDNA samples.

By enhancing the accuracy of tumor identification through AI-driven method, the study opens up mutliple promises when applying in multi-cancer early detection tests:

Improved Data Accuracy: The combination demonstrated exceptional performance in accurately identifying the tumor of origin, notably up to 100%, 98% and 93% accuracies for breast, liver and colorectal cancer.

Reduced Sequencing Depth: By having a guiding atlas, the R&D team can optimize sequencing depth required for tumor identification, making it more efficient and cost-effective. This reduction in sequencing depth not only accelerates the time-to-result but also conserves costly next-generation sequencing resources.

Optimized Analysis Resources: The AI-driven approach optimizes the use of computational resources, reducing the overall cost and time required for tumor analysis. This optimization is a crucial step towards making advanced circulating tumor DNA analysis accessible and affordable for healthcare providers and patients alike.

Dr. Minh Duy Phan, a lead author of the study commented: "The analytical validation of the new tumor methylation atlas and deep learning algorithm marks a significant milestone in circulating tumor DNA analysis for early cancer signal detection. By harnessing the power of AI, we are enhancing the accuracy and efficiency of multi-cancer early detection technology for real-world utility."

Future Developments:

With further development by our data team, Gene Solutions is committed to expanding the capabilities of the TSMA. The ongoing research and development efforts aim to enable better quality analysis and application in real-life practice to reduce the cost of assays, ensuring that cutting-edge cancer screening tools are within reach for recommended individuals worldwide.

For more in-depth information about the study and the TSMA, please visit https://spotmas.com/blog/pioneering-a-tumor-specific-methylation-atlas-tsma-to-identify-tissue-of-origin-too-in-multi-cancer-early-detection/

References:

Nguyen, T.H., Doan, N.N.T., Tran, T.H. et al. Tissue of origin detection for cancer tumor using low-depth cfDNA samples through combination of tumor-specific methylation atlas and genome-wide methylation density in graph convolutional neural networks. J Transl Med 22, 618 (2024), doi: 10.1186/s12967-024-05416-z

Hashtag: #GeneSolutions

The issuer is solely responsible for the content of this announcement.

About Gene Solutions:

Gene Solutions, a pioneering genetic testing company in South-East Asia, empowers healthcare decisions by providing accessible and critical insights. Their services include next-generation sequencing (NGS) tests that support reproductive health and clinical oncology. Gene Solutions specializes in non-invasive prenatal screening (NIPT), minimal residual disease (MRD) monitoring, multi-gene panel liquid biopsy, comprehensive genomic profiling (CGP), and multi-cancer early detection (MCED) tests. Leveraging clinically validated cell-free DNA analysis methods and artificial intelligence applications in bioinformatics, the company is committed to enable precision medicine. With a network of six international standard NGS Laboratories across Southeast Asia, Gene Solutions remains at the forefront of innovative genetic solutions.

The Times Features

Why You Need an Expert Electrician for Your Business’s Electrical Upgrades and Repairs

When it comes to maintaining and upgrading your business’s electrical systems, it’s essential to call in a professional. Electrical work in any commercial setting requires the ex...

Why Is It Crucial to Have a Building Inspection Done Before Buying a New Home?

Purchasing a new property is a big financial decision that can impact your future for years. Whether you are a first-time buyer or an investor, good or bad, it is essential to en...

Online Application for Sick Leave Certificate: Understanding When and How to Secure One

A sick leave certificate is an official document issued by a healthcare professional to verify an individual's inability to attend work due to illness. It typically includes the ...

A No-Fuss Guide to an Effective Beauty Routine

Taking care of the skin and appearance need not be complicated; it need not even consume your hours of time. Smart and simple approaches can give one that glow and fresh look witho...

Safe & Effective Tattoo Removal in Auckland – What You Need to Know

If you're looking for tattoo removal in Auckland, modern laser technology offers the safest and most effective way to fade or completely remove unwanted ink. Whether it's an outd...

Fleece-Lined Tights vs. Regular Tights: What’s the Difference?

When temperatures drop, choosing the right pair of tights can make a significant difference in comfort, warmth, and durability. Whether you wear tights for fashion, work, or outdoo...

Times Magazine

The Ultimate Guide to Apple Watch Faces & Trending Wallpapers

In today’s digital world, personalization is everything. Your smartwatch isn’t just a timepiece—it’s an extension of your style. Thanks to innovative third-party developers, customizing your Apple Watch has reached new heights with stunning designs...

The Power of Digital Signage in Modern Marketing

In a fast-paced digital world, businesses must find innovative ways to capture consumer attention. Digital signage has emerged as a powerful solution, offering dynamic and engaging content that attracts and retains customers. From retail stores to ...

Why Cloud Computing Is the Future of IT Infrastructure for Enterprises

Globally, cloud computing is changing the way business organizations manage their IT infrastructure. It offers cheap, flexible and scalable solutions. Cloud technologies are applied in organizations to facilitate procedures and optimize operation...

First Nations Writers Festival

The First Nations Writers Festival (FNWF) is back for its highly anticipated 2025 edition, continuing its mission to celebrate the voices, cultures and traditions of First Nations communities through literature, art and storytelling. Set to take ...

Improving Website Performance with a Cloud VPS

Websites represent the new mantra of success. One slow website may make escape for visitors along with income too. Therefore it's an extra offer to businesses seeking better performance with more scalability and, thus represents an added attracti...

Why You Should Choose Digital Printing for Your Next Project

In the rapidly evolving world of print media, digital printing has emerged as a cornerstone technology that revolutionises how businesses and creative professionals produce printed materials. Offering unparalleled flexibility, speed, and quality, d...

LayBy Shopping