The Times Australia
The Times World News

.

COVID vaccines for 5 to 11 year olds are inching closer. Here's what we know so far

  • Written by Vasso Apostolopoulos, Professor of Immunology and Associate Provost, Research Partnerships, Victoria University
COVID vaccines for 5 to 11 year olds are inching closer. Here's what we know so far

Australian children aged five to 11 could begin receiving the Pfizer vaccine by the end of November[1], with the nation’s regulator currently reviewing the health and safety data.

Pfizer submitted a partial application[2] to Australia’s Therapeutic Goods Administration (TGA) this week and will supply the remaining data over the next two weeks. The TGA will then review all the information and make a decision about whether to approve the vaccine for use in this age group.

Barring any issues, TGA head John Skerritt expects[3] a decision will be made by the end of November. The Australian Technical Advisory Group on Immunisation (ATAGI), will then advise the government on timing of the rollout.

So what does the data say so far on safety and efficacy? And what are the benefits of vaccinating children aged five to 11?

Why vaccinate children?

While the risk of severe COVID in children is low, a small proportion of children who are infected will become severely unwell, and some of them will die from the virus.

As Delta case numbers rise, so too will the number of serious cases and fatalities. In the United States, children represented more than six million (16.4%)[4] of the total COVID reported cases (8,208 cases per 100,000 children). More than 23,582 US children have been hospitalised and 558 children died (0.01% of child COVID cases).

Read more: How to talk to your child about a COVID diagnosis ... and share the news with others[5]

Multi-system inflammatory syndrome in children (MIS-C)[6] has been reported in children following COVID infection. This can cause multiple parts of the body to become inflamed, including the heart, lungs, eyes, brain, kidneys, skin and gastrointestinal system.

Since May 2020, 5,217 cases of MIS-C have been reported in the United States[7], with a median patient age of nine years; 46 children have died from the condition.

Thankfully, although MIS-C can be serious, most children who are diagnosed with MIS-C recover with medical care.

A young girl in a mask hugs her mother.
The risk of severe disease in children is low, but it’s still possible. Shutterstock[8]

The long term effects of COVID are still unknown. In adults, even mild infection can cause a range of ongoing symptoms of long COVID[9]. These include fatigue, shortness of breath, joint and muscle pain, loss of smell, chest pain and problems with memory, concentration and sleep.

Data from the UK[10] found 9.8% of children aged 2–11 years reported at least one long COVID symptom five weeks after, with other research suggesting they rarely last[11] more than 12 weeks.

However, data from Russia which is yet to be peer reviewed found one-quarter of children discharged from hospital had symptoms more than five months later[12].

Even if a small proportion of children have long-term symptoms, this is of concern, and further studies are required.

Read more: Do kids get long COVID? And how often? A paediatrician looks at the data[13]

There are also other factors to consider. With children under 12 completely unvaccinated, these children can potentially spread the virus to older, vulnerable people.

This may be a particular risk[14] where extended family live together or older relatives care for younger family members.

Are the vaccines safe for children?

This week, the US Food and Drug Administration’s[15] (FDA) independent advisory committee recommended Pfizer[16] be made available to children aged 5-11 years.

When approved, children will receive a reduced dose[17] (one-third of the adult dose) and will receive two doses[18], at the same schedule as adults: approximately three weeks apart.

Masked boy stands outside school, talking to his friends.
Children aged 5-11 will received a third of the adult dose. Shutterstock[19]

In order for the new vaccines to gain approval for a new use, they must undertake their own trials to show they are safe and effective in that population specifically.

A recent submission to the FDA[20] showed a robust immune response following the vaccine. It also provided a good safety profile, with side effects comparable to those seen in a study of 16-25 year olds.

So far, no cases[21] of myocarditis or pericarditis (inflammation of the heart and around the heart) have occurred among the children aged 5-11 in the three months after their second dose.

Read more: The benefits of a COVID vaccine far outweigh the small risk of treatable heart inflammation[22]

However, as the vaccination is rolled out to larger groups, there is a small risk of myocarditis and pericarditis[23].

But the benefits of being vaccinated – in preventing severe disease, hospitalisation and death – outweigh the risk of the rare inflammatory heart conditions, as you can see in the data below.

While the initial studies were not designed to measure efficacy, they showed the vaccine regimen was 90.7% effective[24] at preventing COVID infection.

Of the vaccinated children who developed COVID, symptoms tended to be very mild[25] and didn’t include a fever. Non-vaccinated children generally presented with headaches and fever.

What about the other vaccines?

Early data on Moderna, another mRNA based vaccine, found it was safe and induced strong antibody[26] responses in 6-11 year olds. Children aged 6-11 were given half the adult Moderna dose, twice, 28 days apart.

As with adults and adolescents, the most common side effects in children aged 6-11 from Moderna were fatigue, headache, fever and pain at injection site; the majority were mild or moderate.

Moderna plans to submit the data to the FDA, European Medicines Agency and other regulators in the near future.

The protein-based vaccine Novavax[27], (currently under evaluaton by the TGA), has plans to evaluate its use in younger children, however the necessary trials are long from completion. So far, no preliminary data is available[28].

Read more: What is Novavax, Australia's third COVID vaccine option? And when will we get it?[29]

A study evaluating the AstraZeneca vaccine in children was paused[30] due to safety concerns about blood clots and is unlikely to continue[31].

Should I vaccinate my children?

Given the strong safety and efficacy of the vaccines, and the increasing risk of children contracting COVID as the only remaining population of unvaccinated people, the benefits significantly outweigh the risks.

Vaccination will also play an important role in ensuring vulnerable children can continue to participate in social and educational activities with their peers, and reduce their role in spreading the virus.

It’s OK for parents to have questions about the vaccines. If you do, talk to your GP who can listen your concerns and discuss the evidence and how that relates to your circumstances.

Read more: We may need to vaccinate children as young as 5 to reach herd immunity with Delta, our modelling shows[32]

References

  1. ^ by the end of November (www.smh.com.au)
  2. ^ submitted a partial application (www.health.gov.au)
  3. ^ TGA head John Skerritt expects (www.smh.com.au)
  4. ^ six million (16.4%) (downloads.aap.org)
  5. ^ How to talk to your child about a COVID diagnosis ... and share the news with others (theconversation.com)
  6. ^ (MIS-C) (www.cdc.gov)
  7. ^ been reported in the United States (covid.cdc.gov)
  8. ^ Shutterstock (www.shutterstock.com)
  9. ^ ongoing symptoms of long COVID (www.mayoclinic.org)
  10. ^ Data from the UK (www.nature.com)
  11. ^ they rarely last (www1.racgp.org.au)
  12. ^ five months later (www.medrxiv.org)
  13. ^ Do kids get long COVID? And how often? A paediatrician looks at the data (theconversation.com)
  14. ^ This may be a particular risk (www.webmd.com)
  15. ^ Food and Drug Administration’s (www.health.gov.au)
  16. ^ recommended Pfizer (www.theguardian.com)
  17. ^ reduced dose (www.pfizer.com)
  18. ^ receive two doses (www.reuters.com)
  19. ^ Shutterstock (www.shutterstock.com)
  20. ^ recent submission to the FDA (www.fda.gov)
  21. ^ no cases (www.fda.gov)
  22. ^ The benefits of a COVID vaccine far outweigh the small risk of treatable heart inflammation (theconversation.com)
  23. ^ myocarditis and pericarditis (www.cnbc.com)
  24. ^ 90.7% effective (www.reuters.com)
  25. ^ very mild (www.statnews.com)
  26. ^ strong antibody (www.wsj.com)
  27. ^ Novavax (www.health.gov.au)
  28. ^ no preliminary data is available (www.clinicaltrialsarena.com)
  29. ^ What is Novavax, Australia's third COVID vaccine option? And when will we get it? (theconversation.com)
  30. ^ paused (www.abc.net.au)
  31. ^ is unlikely to continue (mvec.mcri.edu.au)
  32. ^ We may need to vaccinate children as young as 5 to reach herd immunity with Delta, our modelling shows (theconversation.com)

Read more https://theconversation.com/covid-vaccines-for-5-to-11-year-olds-are-inching-closer-heres-what-we-know-so-far-169732

Times Magazine

Building a Strong Online Presence with Katoomba Web Design

Katoomba web design is more than just creating a website that looks good—it’s about building an online presence that reflects your brand, engages your audience, and drives results. For local businesses in the Blue Mountains, a well-designed website a...

September Sunset Polo

International Polo Tour To Bridge Historic Sport, Life-Changing Philanthropy, and Breath-Taking Beauty On Saturday, September 6th, history will be made as the International Polo Tour (IPT), a sports leader headquartered here in South Florida...

5 Ways Microsoft Fabric Simplifies Your Data Analytics Workflow

In today's data-driven world, businesses are constantly seeking ways to streamline their data analytics processes. The sheer volume and complexity of data can be overwhelming, often leading to bottlenecks and inefficiencies. Enter the innovative da...

7 Questions to Ask Before You Sign IT Support Companies in Sydney

Choosing an IT partner can feel like buying an insurance policy you hope you never need. The right choice keeps your team productive, your data safe, and your budget predictable. The wrong choice shows up as slow tickets, surprise bills, and risky sh...

Choosing the Right Legal Aid Lawyer in Sutherland Shire: Key Considerations

Legal aid services play an essential role in ensuring access to justice for all. For people in the Sutherland Shire who may not have the financial means to pay for private legal assistance, legal aid ensures that everyone has access to representa...

Watercolor vs. Oil vs. Digital: Which Medium Fits Your Pet's Personality?

When it comes to immortalizing your pet’s unique personality in art, choosing the right medium is essential. Each artistic medium, whether watercolor, oil, or digital, has distinct qualities that can bring out the spirit of your furry friend in dif...

The Times Features

Wedding Photography Trends You Need to Know (Before You Regret Your Album)

Your wedding album should be a timeless keepsake, not something you cringe at years later. Trends may come and go, but choosing the right wedding photography approach ensures your ...

Can you say no to your doctor using an AI scribe?

Doctors’ offices were once private. But increasingly, artificial intelligence (AI) scribes (also known as digital scribes) are listening in. These tools can record and trans...

There’s a new vaccine for pneumococcal disease in Australia. Here’s what to know

The Australian government announced last week there’s a new vaccine[1] for pneumococcal disease on the National Immunisation Program for all children. This vaccine replaces pr...

What Makes a Small Group Tour of Italy So Memorable?

Traveling to Italy is on almost every bucket list. From the rolling hills of Tuscany to the sparkling canals of Venice, the country is filled with sights, flavors, and experiences ...

Latest data suggests Australia is overcoming its sugar addiction

Australia is now meeting the World Health Organization’s (WHO) guidelines[1] on sugar, which recommend keeping sugar below 10% of daily energy intake. New data[2] published ...

Do you really need a dental check-up and clean every 6 months?

Just over half of Australian adults[1] saw a dental practitioner in the past 12 months, most commonly for a check-up[2]. But have you been told you should get a check-up and c...