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Neuralink has put its first chip in a human brain. What could possibly go wrong?

  • Written by Nathan Higgins, PhD candidate in Psychology, Monash University
Neuralink has put its first chip in a human brain. What could possibly go wrong?

Earlier this week, Elon Musk announced[1] his brain-computer interface company, Neuralink, had implanted a device in a human for the first time. The company’s PRIME[2] study, approved by the US Food and Drug Administration last year, is testing a brain implant for “people with paralysis to control external devices with their thoughts”.

In the past few years, Neuralink has faced investigation for mistreatment of lab animals[3] and seen the departure of several company executives[4]. Nevertheless, the PRIME trial is a significant milestone for a company less than ten years old.

However, Neuralink’s challenges are far from over. Implanting a device is just the beginning of a decades-long clinical project beset with competitors, financial hurdles and ethical quandaries.

Decades of development

The first reported demonstration[5] of a brain-computer interface occurred in 1963. During a lecture at the University of Oxford, neuroscientist William Grey Walter bewildered his audience by linking one of his patient’s brains to the projector, where they advanced the slides of his presentation using only their thoughts.

However, the current wave of exploration in using brain-recording techniques to restore movement and communication to patients with severe paralysis began in the early 2000s. It draws on studies from the 1940s which measured the activity of single neurons, and more complex experiments on rats and monkeys in the 1990s.

Read more: Neuralink put a chip in Gertrude the pig's brain. It might be useful one day[6]

Neuralink’s technology belongs to the next generation of recording devices. These have multiple electrodes, greater precision, and are safer, longer-lasting, and more compatible with the body. The Neuralink implant[7] is thinner, smaller and less obtrusive than the “Utah array” device, widely used in existing brain-computer interfaces, which has been available since 2005.

Neuralink’s device is implanted by a special robot which rapidly inserts polymer threads, each containing dozens of electrodes. In total, the device has 3,072 electrodes – dwarfing the 100 electrodes of the Utah array.

Competitors

Neuralink faces stiff competition in the race to commercialise the first next-generation brain-computer interface.

Arguably its most fierce competitor is an Australian company called Synchron[8]. This Melbourne-based start-up recently used a microelectrode mesh threaded through the blood vessels of the brain. This allowed paralysed patients to use tablets and smartphones, surf the internet, send emails, manage finances (and post on X[9], formerly Twitter).

Read more: We've been connecting brains to computers longer than you’d expect. These 3 companies are leading the way[10]

The Synchron implant is described as a “minimally invasive” brain-computer interface. It requires only a minor incision in the neck, rather than the elaborate neurosurgery required by Neuralink and most other brain-computer interfaces.

In 2021, Synchron received a “Breakthrough Device Designation[11]” in the United States, and is now onto its third clinical trial.

Patient welfare

This competitive landscape raises potential ethical issues concerning the welfare of patients in the PRIME study. For one, it is notoriously difficult to recruit participants to neural implant studies. Patients must meet strict criteria to be eligible, and the trials are inherently risky and ask a lot of participants.

Musk’s public profile may help Neuralink find and enrol suitable patients. However, the company will need to be prepared to provide long-term support (potentially decades) to patients. If things go wrong, patients may need support to live with the consequences; if things go right, Neuralink may need to make sure the devices don’t stop working.

In 2022, a company called Second Sight Medical Product demonstrated the risks. Second Sight made retinal implants to treat blindness. When the company went bankrupt[12], it left more than 350 patients around the world with obsolete implants and no way to remove them.

If Neuralink’s devices are successful, they are likely to transform patients’ lives. What happens if the company winds up operations because it can’t make a profit? A plan for long-term care is essential.

What’s more, the considerable hype surrounding Neuralink may have implications for obtaining informed consent from potential participants.

Musk famously compared[13] the implant to a “Fitbit in your skull”. The device itself, Musk recently revealed, is misleadingly named “Telepathy”.

This techno-futurist language may give participants unrealistic expectations about the likelihood and kind of individual benefit. They may also underappreciate the risks, which could include severe brain damage.

The way forward

In this next chapter of the Neuralink odyssey, Musk and his team must maintain a strong commitment to research integrity and patient care. Neuralink’s establishment of a patient registry[14] to connect with patient communities is a step in the right direction.

Long-term planning and careful use of language will be necessary to preventing harm to patients and families.

The nightmare scenario for all neurotechnology research would be a repeat of Walter Freeman’s disastrous pre-frontal lobotomy experiments[15] in the 1940s and 1950s. These had catastrophic consequences for patients and set research back by generations.

References

  1. ^ announced (twitter.com)
  2. ^ PRIME (neuralink.com)
  3. ^ mistreatment of lab animals (www.theguardian.com)
  4. ^ departure of several company executives (futurism.com)
  5. ^ first reported demonstration (pubmed.ncbi.nlm.nih.gov)
  6. ^ Neuralink put a chip in Gertrude the pig's brain. It might be useful one day (theconversation.com)
  7. ^ Neuralink implant (www.jmir.org)
  8. ^ Synchron (theconversation.com)
  9. ^ post on X (twitter.com)
  10. ^ We've been connecting brains to computers longer than you’d expect. These 3 companies are leading the way (theconversation.com)
  11. ^ Breakthrough Device Designation (www.businesswire.com)
  12. ^ went bankrupt (spectrum.ieee.org)
  13. ^ famously compared (www.forbes.com)
  14. ^ patient registry (neuralink.com)
  15. ^ disastrous pre-frontal lobotomy experiments (www.theguardian.com)

Read more https://theconversation.com/neuralink-has-put-its-first-chip-in-a-human-brain-what-could-possibly-go-wrong-222497

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