What is delirium?

Delirium is a sudden decline in a person’s usual mental function. It occurs when signals in the brain aren’t sending and receiving properly, causing confusion in thinking and altered behaviour or levels of consciousness.

Delirium isn’t a disease – it’s a clinical syndrome or condition that is usually temporary and treatable. It’s often mistaken^[1] for dementia because both conditions have similar symptoms, such as confusion, agitation and delusions. If a health-care professional doesn’t know the patient, it can be difficult to tell the difference.

Read more: How much memory loss is normal with ageing?^[2]

Up to one-third^[3] of older people admitted to hospital are diagnosed with delirium. This increases the risk of unnecessary functional decline, a longer hospital stay, falls, needing to be admitted to a residential aged care facility, and death.

However, identifying the condition early reduces these risks. Delirium can also be prevented by identifying who is vulnerable to the condition and finding ways of reducing the person’s risk.

What causes delirium?

Delirium is usually caused by a number of underlying acute (short-term) illnesses and medical complications. Elderly people are vulnerable to delirium because their bodies have fewer reserves^[4] than younger people to respond to these stressors. People with dementia are particularly at risk.

Factors that cause or increase the risk of delirium include:

• malnutrition
• dehydration
• new medications
• a fall
• surgery
• infection
• admission to the intensive care unit
• multiple bed moves
• pain.

A diagnosis of delirium is made on the basis of clinical history, behavioural observation and a cognitive assessment by a clinician trained to assess delirium.

The patient and their family or carer should also be asked about any recent changes in the patient’s behaviour or thinking.

So how can it be prevented or treated?

Clinical care focuses on preventing delirium, managing risk factors and symptoms, and reducing the chance of complications, which prolong or worsen the condition.

To help prevent delirium we can:

• frequently reorient the person (reminding them of their location, the date and time)
• encourage the person to get out of bed and, where appropriate, to walk around, while ensuring they’re safe from falling
• manage their pain
• ensure adequate nutrition and hydration
• reduce their sensory impairments (helping them put on glasses and hearing aids and ensuring they’re working)
• ensure proper sleep patterns.

Why is delirium under-diagnosed?

While delirium is potentially preventable, it’s poorly recognised, and cases are often missed. This is due to^[6] inadequate knowledge among the attending health-care staff, a lack of routine formal screening and assessment, and health-care staff not knowing the patient.

Diagnosing delirium can be difficult when symptoms fluctuate during the day. Changes in alertness come and go^[7], with people usually more alert in the morning and less so at night.

Read more: Preventing delirium protects seniors in hospital, but could also ease overcrowding and emergency room backlogs^[8]

Delirium is also under-recognised because it can present very differently. In some people it can result in hyperactivity (hallucinations, delusions or uncooperative behaviour), and in other people, hypoactivity (decreased arousal which can be mistaken for fatigue or depression), or mixture of both.

Around 50%^[9] of people who are discharged from hospital with unresolved delirium symptoms can experience symptoms lasting for months. Alarmingly, some people transition into permanent states of cognitive impairment.

Delirium takes a toll on carers

Delirium costs^[10] the Australian government around^[11] A$8.8 billion a year.

The greater cost, however, is that experienced by the patient and their family. The sudden change in a person’s behaviour and/or emotions as a result of delirium causes high levels of stress and anxiety for family carers.

Carers of older adults diagnosed with delirium report^[13] high levels of psychological distress, poor wellbeing and less satisfaction^[14] with life because of their care-giving role.

The identification and management of risk for delirium is therefore imperative for safe and quality care for both patients and their family.

Partnering with family carers

Partnering with family carers can improve the care outcomes for older people who are hospitalised.

Family carers and friends are well placed to detect changes in patients’ cognition and behaviour. Close family members, in particular, have intimate knowledge about the person’s previous mental state and can identify subtle changes in their behaviour.

However, many carers of patients discharged from hospital with delirium receive little advice or ongoing support. Despite recent clinical standards^[15] recommending family carers be active participants in care, they’re often left out. This has been compounded^[16] by the COVID pandemic.

Read more: Delirium, depression, anxiety, PTSD – the less discussed effects of COVID-19^[17]

To address this shortfall, we have developed a model of care to support the integration of carers as partners in the prevention and management of delirium to improve health outcomes.

Using a web-based toolkit, we’re hoping to increase awareness and knowledge of delirium among carers of older adults in hospital who are at risk of delirium. It also aims to support the carer’s wellbeing.

The toolkit is currently being trialled and evaluated at Tweed Hospital and, if successful, could be rolled out to all hospitals.

References

1. ^{^} often mistaken (www.nice.org.uk)
2. ^{^} How much memory loss is normal with ageing? (theconversation.com)
3. ^{^} Up to one-third (www.thelancet.com)
4. ^{^} reserves (www.thelancet.com)
5. ^{^} Shutterstock (www.shutterstock.com)
6. ^{^} due to (www.ncbi.nlm.nih.gov)
7. ^{^} come and go (www.nature.com)
8. ^{^} Preventing delirium protects seniors in hospital, but could also ease overcrowding and emergency room backlogs (theconversation.com)
9. ^{^} Around 50% (doi.org)
10. ^{^} costs (bmjopen.bmj.com)
11. ^{^} around (www.ihacpa.gov.au)
12. ^{^} Shutterstock (www.shutterstock.com)
13. ^{^} report (academic.oup.com)
14. ^{^} satisfaction (pubmed.ncbi.nlm.nih.gov)
15. ^{^} clinical standards (www.safetyandquality.gov.au)
16. ^{^} compounded (associationofanaesthetists-publications.onlinelibrary.wiley.com)
17. ^{^} Delirium, depression, anxiety, PTSD – the less discussed effects of COVID-19 (theconversation.com)