Drugs like Ozempic won’t ‘cure’ obesity but they might make us more fat-phobic

Hundreds of thousands of people worldwide are taking drugs like Ozempic to lose weight. But what do we actually know about them? This month, The Conversation’s experts explore their rise, impact and potential consequences^[1].

Many have declared^[2] drugs like Ozempic could “end obesity” by reducing the appetite and waistlines of millions of people around the world.

When we look past the hype, this isn’t just untrue – it can also be harmful. The focus on weight, as opposed to health, is a feature of diet culture^[3]. This frames the pursuit of thinness as more important than other aspects of physical and cultural wellbeing.

The Ozempic buzz isn’t just rooted in health and medicine but plays into ideas of fat stigma and fat phobia^[4]. This can perpetuate fears of fatness and fat people, and the behaviours that harm people who live in larger bodies^[5].

Not the first ‘miracle’ weight-loss drug

This isn’t the first time we have heard that weight-loss drugs will change the world. Ozempic and its family^[6] of GLP-1-mimicking drugs are the latest in a long line of weight loss drugs^[7]. Each looked promising at the time. But none have lived up to the hype in the long term. Some have even been withdrawn from sale due to severe side effects^[8].

Read more: Ozempic is in the spotlight but it's just the latest in a long and strange history of weight-loss drugs^[9]

Science does improve incrementally^[10], but diet culture also keeps us on a cycle of hope for the next miracle cure^[11]. So drugs like Ozempic might not deliver the results individuals expect, continuing the cycle of hope and shame.

Ozempic doesn’t work the same for everyone

When we talk about the results of studies using Ozempic, we often focus on the average^[12] (also known as the mean) results or the maximum (or peak) results. So, studies might show^[13] those using the drug lost an average of 10.9% of their body weight, but some lost more than 20% and others less than 5%

What we don’t talk about as much is that responses are variable. Some people are “non-responders^[14]”. This means not everyone loses as much weight as the average, and some don’t lose weight at all. For some people, the side-effects will outweigh the benefits.

Read more: Considering taking a weight-loss drug like Ozempic? Here are some potential risks and benefits^[15]

When people are on drugs like Ozempic, their blood sugar is better controlled by enhancing the release of insulin and reducing the levels of another hormone called glucagon.

But there is greater variability in the amount of weight lost^[16] than the variability in blood sugar control. It isn’t clear why, but is likely due to differences in genetics and lifestyles, and weight being more complex to regulate.

Treatment needs to be ongoing. What will this mean?

When weight-loss drugs do work, they are only effective while they’re being taken. This means that to keep the weight off people need to keep taking them long term. One study found^[17] an average weight loss of more than 17% after a year on Ozempic became an average net weight loss of 5.6% more than two years after stopping treatment.

Short-term side effects of drugs like Ozempic include dizziness, nausea, vomiting and other gastrointestinal upsets. But because these are new drugs, we simply don’t have data to tell us if side effects will increase as people take them for longer periods.

Nor do we know if effectiveness will be reduced^[19] in the long term. This is called drug tolerance^[20] and is documented for other long-term treatments such as antidepressants and chemotherapies.

Biology is only part of the story

For some people, using GLP-1-mimicking drugs like Ozempic will be validating and empowering. They will feel like their biology has been “normalised” in the same way that blood pressure or cholesterol medication can return people to the “normal” range of measures.

But biologically, obesity isn’t solely about GLP-1 activity^[21] with many other^[22] hormones, physical activity, and even our gut microbes involved.

Overall, obesity is complex and multifaceted^[23]. Obesity isn’t just driven by personal biology and choice; it has social, cultural, political, environmental and economic determinants.

A weight-centred approach misses the rest of the story

The weight-centred approach suggests that leading with thinness means health will follow^[24]. But changing appetite is only part of the story when it comes to health.

Obesity often co-exists with malnutrition^[25]. We try to separate the effects in research using statistics, but focusing on the benefits of weight-loss drugs without addressing the underlying malnutrition means we aren’t likely to see the improved health outcomes in everyone who loses weight^[26].

Read more: How dieting, weight suppression and even misuse of drugs like Ozempic can contribute to eating disorders^[27]

Obesity isn’t an issue detached from people

Even when it is well-intentioned, the rhetoric around the joy of “ending the obesity epidemic” can harm people^[28]. Obesity doesn’t occur in isolation. It is people who are obese. And the celebration and hype of these weight-loss drugs can reinforce harmful fat stigma.

The framing of these drugs as a “cure” exacerbates the binary view of thin versus fat, and healthy versus unhealthy. These are not binary outcomes that are good or bad. Weight and health exist on a spectrum.

Ironically, while fat people are told they need to lose weight for their health, they are also shamed for “cheating” or taking shortcuts^[30] by using medication.

Read more: Ozempic, the 'miracle drug,' and the harmful idea of a future without fat^[31]

Drugs are tools, not silver bullets

The creation of these drugs is a start, but they remain expensive, and the hype has been followed by shortages^[32]. Ultimately, complex challenges aren’t addressed with simple solutions. This is particularly true when people are involved, and even more so when there isn’t even an agreement on what the challenge is.

Many organisations and individuals see obesity is a disease and believe this framing helps people to seek treatment.

Others think it’s unnecessary to attach medical labels to body types and argue^[33] it confuses risk factors (things that are linked to increased risk of illness) with illness itself.

Regardless, two things will always remain true. Drugs can only ever be tools, and those tools need to be applied in a context. To use these tools ethically, we need to remain mindful of who this application harms along the way.

Read the other articles in The Conversation’s Ozempic series^[34] here.

References

1. ^{^} explore their rise, impact and potential consequences (theconversation.com)
2. ^{^} declared (www.economist.com)
3. ^{^} diet culture (www.sciencedirect.com)
4. ^{^} fat stigma and fat phobia (butterfly.org.au)
5. ^{^} harm people who live in larger bodies (link.springer.com)
6. ^{^} its family (www.ncbi.nlm.nih.gov)
7. ^{^} latest in a long line of weight loss drugs (theconversation.com)
8. ^{^} severe side effects (www.ncbi.nlm.nih.gov)
9. ^{^} Ozempic is in the spotlight but it's just the latest in a long and strange history of weight-loss drugs (theconversation.com)
10. ^{^} incrementally (www.thelancet.com)
11. ^{^} miracle cure (sahrc.org)
12. ^{^} focus on the average (www.ncbi.nlm.nih.gov)
13. ^{^} show (www.ncbi.nlm.nih.gov)
14. ^{^} non-responders (www.sciencedirect.com)
15. ^{^} Considering taking a weight-loss drug like Ozempic? Here are some potential risks and benefits (theconversation.com)
16. ^{^} weight lost (www.sciencedirect.com)
17. ^{^} One study found (www.ncbi.nlm.nih.gov)
18. ^{^} Manop Boonpeng/Shutterstock (www.shutterstock.com)
19. ^{^} effectiveness will be reduced (www.medicalnewstoday.com)
20. ^{^} drug tolerance (www.cancer.gov)
21. ^{^} isn’t solely about GLP-1 activity (www.ncbi.nlm.nih.gov)
22. ^{^} many other (www.worldobesity.org)
23. ^{^} obesity is complex and multifaceted (www.ncbi.nlm.nih.gov)
24. ^{^} suggests that leading with thinness means health will follow (butterfly.org.au)
25. ^{^} co-exists with malnutrition (www.sciencedirect.com)
26. ^{^} improved health outcomes in everyone who loses weight (www.wsj.com)
27. ^{^} How dieting, weight suppression and even misuse of drugs like Ozempic can contribute to eating disorders (theconversation.com)
28. ^{^} harm people (theconversation.com)
29. ^{^} Zoran Zeremski/Shutterstock (www.shutterstock.com)
30. ^{^} shamed for “cheating” or taking shortcuts (www.dailytelegraph.com.au)
31. ^{^} Ozempic, the 'miracle drug,' and the harmful idea of a future without fat (theconversation.com)
32. ^{^} shortages (www.tga.gov.au)
33. ^{^} argue (www.forbes.com)
34. ^{^} Ozempic series (theconversation.com)