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An RSV vaccine has been approved for people over 60. But what about young children?

  • Written by Allen Cheng, Professor of Infectious Diseases, Monash University
An RSV vaccine has been approved for people over 60. But what about young children?

The Therapeutic Goods Administration (TGA) has approved[1] a vaccine against respiratory syncytial virus (RSV) in Australia for the first time. The shot, called Arexvy and manufactured by GSK, will be available by prescription to adults over 60.

RSV is a contagious respiratory virus which causes an illness similar to influenza, most notably in babies and older adults.

So while it will be good to have an RSV vaccine available for older people, where is protection up to for the youngest children?

Read more: What happens in our body when we encounter and fight off a virus like the flu, SARS-CoV-2 or RSV?[2]

A bit about RSV

RSV was discovered[3] in chimpanzees with respiratory illness in 1956, and was soon found to be a common cause of illness in humans.

There are two key groups of people we would like to protect from RSV: babies (up to about one year old) and people older than 60.

Babies tend to fill up hospitals[4] during the RSV season in late spring and winter in large numbers, but severe infection requiring admission to intensive care is less common.

In babies and younger children, RSV generally causes a wheezing asthma-like illness (bronchiolitis), but can also cause pneumonia and croup.

Although there are far fewer hospital admissions among older people, they can develop severe disease and die[5] from an infection.

A baby sitting on a bed.
Babies account for the majority of hospitalisations with RSV. Prostock-studio/Shutterstock[6]

RSV vaccines for older people

For older adults, there are actually several RSV vaccines in the pipeline. The recent Australian TGA approval[7] of Arexvy is likely to be the first of several, with other vaccines from Pfizer and Moderna currently in development.

The GSK and Pfizer RSV vaccines are similar. They both contain a small component of the virus, called the pre-fusion protein[8], that the immune system can recognise.

Both vaccines have been[9] shown[10] to reduce illness from RSV by more than 80% in the first season after vaccination.

Read more: Is there a vaccine for RSV or respiratory syncytial virus? After almost 60 years, several come at once[11]

In older adults, side effects following Arexvy appear to be similar[12] to other vaccines, with a sore arm and generalised aches and fatigue frequently reported.

Unlike influenza vaccines which are given each year, it is anticipated the RSV vaccine would be a one-off dose[13], at least at this stage.

Protecting young children from RSV

Younger babies don’t tend to respond[14] well to some vaccines due to their immature immune system. To prevent other diseases, this can be overcome by giving multiple vaccine doses over time. But the highest risk group for RSV are those in the first few months of life.

To protect this youngest age group from the virus, there are two potential strategies available instead of vaccinating the child directly.

The first is to give a vaccine to the mother and rely on the protective antibodies passing to the infant through the placenta. This is similar to how we protect[15] babies by vaccinating pregnant women against influenza and pertussis (whooping cough).

The second is to give antibodies directly to the baby as an injection. With both these strategies, the protection provided is only temporary as antibodies wane over time, but this is sufficient to protect infants through their highest risk period.

A pregnant woman receives a vaccination.
Women could be vaccinated during pregnancy to protect their baby in its first months of life. Image Point Fr/Shutterstock[16]

Abrysvo, the Pfizer RSV vaccine, has been trialled[17] in pregnant women. In clinical trials, this vaccine has been shown to reduce illness in infants for up to six months. It has been approved[18] in pregnant women in the United States, but is not yet approved in Australia.

An antibody product called palivizumab has been available for many years, but is only partially effective[19] and extremely expensive[20], so has only been given to a small number of children at very high risk.

A newer antibody product, nirsevimab, has been shown[21] to be effective in reducing infections and hospitalisations in infants. It was approved[22] by the TGA in November, but it isn’t yet clear how this would be accessed in Australia.

Read more: How common are severe side effects from COVID vaccines? And how are they detected?[23]

What now?

RSV, like influenza, is a major cause of respiratory illness, and the development of effective vaccines represents a major advance.

While the approval of the first vaccine for older people is an important step, many details are yet to be made available, including the cost and the timing of availability. GSK has indicated[24] its vaccine should be available soon. While the vaccine will initially only be available on private prescription (with the costs paid by the consumer), GSK has applied for it to be made free under the National Immunisation Program.

In the near future, we expect to hear further news about the other vaccines and antibodies to protect those at higher risk from RSV disease, including young children.

References

  1. ^ has approved (www.theguardian.com)
  2. ^ What happens in our body when we encounter and fight off a virus like the flu, SARS-CoV-2 or RSV? (theconversation.com)
  3. ^ discovered (www.ncbi.nlm.nih.gov)
  4. ^ fill up hospitals (www.mja.com.au)
  5. ^ severe disease and die (www.ncbi.nlm.nih.gov)
  6. ^ Prostock-studio/Shutterstock (www.shutterstock.com)
  7. ^ TGA approval (www.abc.net.au)
  8. ^ pre-fusion protein (www.nejm.org)
  9. ^ been (www.nejm.org)
  10. ^ shown (www.nejm.org)
  11. ^ Is there a vaccine for RSV or respiratory syncytial virus? After almost 60 years, several come at once (theconversation.com)
  12. ^ appear to be similar (www.nejm.org)
  13. ^ one-off dose (www.cdc.gov)
  14. ^ tend to respond (www.sciencedirect.com)
  15. ^ protect (pubmed.ncbi.nlm.nih.gov)
  16. ^ Image Point Fr/Shutterstock (www.shutterstock.com)
  17. ^ trialled (www.nejm.org)
  18. ^ approved (www.fda.gov)
  19. ^ partially effective (www.ncbi.nlm.nih.gov)
  20. ^ expensive (pubmed.ncbi.nlm.nih.gov)
  21. ^ shown (www.nejm.org)
  22. ^ approved (www.tga.gov.au)
  23. ^ How common are severe side effects from COVID vaccines? And how are they detected? (theconversation.com)
  24. ^ indicated (www.abc.net.au)

Read more https://theconversation.com/an-rsv-vaccine-has-been-approved-for-people-over-60-but-what-about-young-children-221311

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