We calculated the impact of 'long COVID' as Australia opens up. Even without Omicron, we're worried

Over the past two years, we’ve learned COVID-19 survivors can develop a range of longer-term symptoms we now call “long COVID^[1]”. This includes people who did not have severe illness initially.

Such longer-term symptoms^[2] can affect multiple systems in the body. This can result in ongoing, severe fatigue plus a wide range of other symptoms, including pain, as well as breathing, neurological, sleep and mental health problems.

So far, Australia has had far fewer COVID-19 cases than many other nations. But as we re-open^[3], this situation may change. So we will likely see more long COVID in the months and years ahead.

Read more: The mystery of 'long COVID': up to 1 in 3 people who catch the virus suffer for months. Here's what we know so far^[4]

Our research, which we posted online as a pre-print^[5] and so has yet to be independently verified, examined the shifting burden of disease of COVID-19 as Australia re-opens and as high vaccination rates reduce mortality and severe illness.

We show how long COVID will increasingly drive the burden of COVID illness, even as death rates decline.

We also estimate^[6] the likely numbers of long COVID cases we can expect in Australia over the two years following reopening.

We wrote this briefing paper^[7] before the rise of Omicron, the impact of which we’re yet to fully understand.

Read more: Will omicron – the new coronavirus variant of concern – be more contagious than delta? A virus evolution expert explains what researchers know and what they don't^[8]

Here’s what we did and what we found

We examined the 2021 Delta outbreaks in Victoria^[9] and New South Wales^[10] in which nearly 140,000 people had been infected by the end of October.

We estimated long COVID prevalence using two sources. A large dataset from the UK^[11] found more than 13% of people had symptoms after 12 weeks. A much smaller study conducted in NSW^[12] found about 5% had symptoms over roughly the same period.

Our modelling suggests, by the end of October, the combined Victoria and NSW outbreaks may have already led to^[13] 9,450–19,800 people having developed long COVID that could last 12 weeks after their COVID infection.

Even more will have experienced long COVID symptoms for a shorter time: 34,000-44,500 people will likely have symptoms for at least three weeks after first becoming ill, but our model indicates more than half will then recover over the following nine weeks.

Read more: Will Australia follow Europe into a fourth COVID wave? Boosters, vaccinating kids, ventilation and masks may help us avoid it^[14]

We also estimated the likely consequences for long COVID if we follow Australia’s national re-opening plan, based on interim modelling from the Doherty Institute^[15], which has since been updated.

The Doherty Institute modelled various scenarios with different vaccination rates and public health measures in place. These gave different estimates of COVID-19 cases. We combined these with our upper and lower estimates for long COVID prevalence.

We calculated that more limited relaxation of public health measures could generate 10,000-34,000 long COVID cases (people with symptoms lasting at least 12 weeks). More complete relaxation of public health measures could lead to 60,000-133,000 long COVID cases.

Based on the longer-term UK data for long COVID prevalence, we calculated 2,000-11,000 people might still be sick a year after their initial infection.

What we cannot be absolutely certain about is the impact of vaccination on the expected number of long COVID cases. Some studies suggest that if vaccinated people become infected, this reduces their chance of developing long COVID, but the evidence remains uncertain^[16].

Read more: We shouldn't lift all COVID public health measures until kids are vaccinated. Here's why^[17]

Many impacts, beyond health

Long COVID can be a debilitating and distressing health condition. It also has a number of economic impacts, for the health system and people’s ability to work.

For instance, people with long COVID require coordinated care^[18] across a range of different health services and specialties.

Recent data from the UK’s Office for National Statistics^[19] indicate that around 1.2 million people reported long COVID symptoms in the four weeks to the end of October. The UK health secretary said he was alarmed^[20] at the growing scale of this problem for the National Health Service.

Indeed, attempts to provide long COVID care through specialised hospital-based clinics in the UK and elsewhere have led to long waiting times and uneven access^[21].

References

1. ^{^} long COVID (theconversation.com)
2. ^{^} longer-term symptoms (www.who.int)
3. ^{^} re-open (www.australia.gov.au)
4. ^{^} The mystery of 'long COVID': up to 1 in 3 people who catch the virus suffer for months. Here's what we know so far (theconversation.com)
5. ^{^} online as a pre-print (www.researchsquare.com)
6. ^{^} also estimate (iht.deakin.edu.au)
7. ^{^} briefing paper (iht.deakin.edu.au)
8. ^{^} Will omicron – the new coronavirus variant of concern – be more contagious than delta? A virus evolution expert explains what researchers know and what they don't (theconversation.com)
9. ^{^} Victoria (www.coronavirus.vic.gov.au)
10. ^{^} New South Wales (www.health.nsw.gov.au)
11. ^{^} from the UK (www.ons.gov.uk)
12. ^{^} conducted in NSW (www.sciencedirect.com)
13. ^{^} have already led to (iht.deakin.edu.au)
14. ^{^} Will Australia follow Europe into a fourth COVID wave? Boosters, vaccinating kids, ventilation and masks may help us avoid it (theconversation.com)
15. ^{^} Doherty Institute (www.doherty.edu.au)
16. ^{^} the evidence remains uncertain (www.nature.com)
17. ^{^} We shouldn't lift all COVID public health measures until kids are vaccinated. Here's why (theconversation.com)
18. ^{^} coordinated care (ahha.asn.au)
19. ^{^} Office for National Statistics (www.ons.gov.uk)
20. ^{^} said he was alarmed (www.independent.co.uk)
21. ^{^} long waiting times and uneven access (www.thetimes.co.uk)
22. ^{^} Shutterstock (www.shutterstock.com)
23. ^{^} focus urgently on (ahha.asn.au)
24. ^{^} already battered (www.mja.com.au)
25. ^{^} particularly at risk (pubmed.ncbi.nlm.nih.gov)
26. ^{^} 6 ways to prevent a mass exodus of health workers (theconversation.com)
27. ^{^} more severely affected (www.theguardian.com)
28. ^{^} Social media, activism, trucker caps: the fascinating story behind long COVID (theconversation.com)